Obesity Abstracts

Background: Seizures post-bariatric surgery are rarely reported yet are clinically significant. Severe postprandial hypoglycaemia can present as seizures in a patient with a history of bariatric surgery. However, differentiating between primary seizure disorders and hypoglycaemia-causing seizures can be challenging.History: A 57-year-old female presented to our bariatric clinic with frequent seizures, occurring approxima...

Obesity is an important modifiable risk factor for developing osteoarthritis. Arthroplasty improves mobility and quality of life in those with osteoarthritis. BMI thresholds are mandated by some commissioning bodies in the UK, leading to extended waiting times for arthroplasty. Obesity is associated with increased complications after arthroplasty. It is unknown if these risks can be mitigated by weight loss pre-operatively. Our systematic review and meta-analysis explores the ...

The impact of obesity on fertility and pregnancy is well-established. The literature remains conflicting around optimal BMI threshold and weight loss strategy on reproductive outcomes. We describe a series of twenty-six women with obesity that were planning a future pregnancy or seeking assisted fertility services. They were initially reviewed for weight management at Imperial College Healthcare between September 2020 and September 2022. Clinical case information was retrieved...

Idiopathic intracranial hypertension (IIH) classically occurs in women with obesity and is characterised by raised intracranial pressure. Weight loss leads to reduction in intracranial pressure. We present a case of a 35-year-old female who was urgently referred to Imperial Weight Centre. She had recently undergone revision of a right ventriculoperitoneal shunt for longstanding IIH which had not resolved her high-pressure symptoms and continued to require therapeutic lumbar pu...

Background: Resting energy expenditure (REE) and diet induced thermogenesis (DIT) are known to influence long term maintenance of weight loss following bariatric surgery. Although it is known that fat free mass (FFM) contributes to REE to a greater extent than fat mass (FM), there has been relatively little work looking at the REE:FFM ratio and its overall effect on and relationship to weight loss.Aim: To assess weight loss, REE and REE:MMT ratio in pati...

Background: Hyperglucagonaemia is one of the key players in the pathophysiology of type 2 diabetes. Roux-en-Y Gastric Bypass (RYGB) is currently a highly effective treatment for weight loss and diabetes remission. However, the role of glucagon in the above effects is unclear.Aim: To characterise the behaviour of proglucagon-derived peptides (glucagon, glucagon-like peptide-1, oxyntomodulin, glicentin) after RYGB surgery.Subjects an...

Background: Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy are two widely used bariatric procedures. Longitudinal data have shown similar efficacy in terms of sustained weight loss and diabetes remission in obese patients with type 2 diabetes. Altered glucose dynamics with increased glycaemic variability and the occurrence of hypoglycaemia are common post-bariatric surgery. Aim: To compare the glycaemic variability and incidence of hypoglycaemia ...

Until recently, only two medications were licenced and approved by the National Institute of Health and Care Excellence (NICE) for weight loss, orlistat and liraglutide. Semaglutide 2.4mg was launched in September 2023. Both liraglutide and semaglutide belong to a class of drugs called GLP-1 analogues, also used in the treatment of Type 2 diabetes. Successful weight loss outcomes for GLP-1 analogues has led to increased global demand and shortages. In June 2023, a National Pat...